As we age, our body’s ability to maintain healthy and flexible joints diminishes. This can lead to stiffness, pain, and decreased mobility. Physio Flex Pro Joint Supplement is a nutritional supplement designed to support joint health and help alleviate joint-related discomfort. In this blog, we will discuss what Physio Flex Pro Joint Supplement is, how it works, its ingredients including Bioperine, reviews, and its potential benefits including use in Kashin Beck disease, and possible side effects.Â
What is Physio Flex Pro Joint Supplement?
Physio Flex Pro Joint Supplement is a nutritional supplement that contains a blend of natural ingredients that support joint health. The supplement is designed to help reduce joint stiffness, improve joint mobility, and alleviate joint-related discomfort. It is made in the USA in cGMP-approved facilities and sold by Bioperine, Sabinsa Corporation. Let us review the facts about how this supplement might work, reviews on its ingredients, and its possible side effects.
How does Physio Flex Pro Joint Supplement Work?
Physio Flex Pro Joint Supplement works by delivering key nutrients that support joint health. On reviewing the literature on the ingredients of Physio Flex Pro, it was observed that these supplements might work together in improving joint health in arthritis and Kashin Beck disease.
For example, Physio Flex Pro contains Glucosamine and chondroitin which are both natural compounds found in cartilage, which is the tissue that cushions joints. There are several studies and reviews available where these compounds have been shown to support the structure and function of joints. MSM is another natural compound that has anti-inflammatory properties and reviews are available that it has been shown to reduce joint pain and stiffness.Â
The combination of the above ingredients in Physio Flex Pro Joint Supplement works synergistically to support joint health. The supplement delivers key nutrients to the body that are needed for healthy joint function, which can help alleviate joint-related discomfort and improve mobility.
What are Physio Flex Pro Ingredients?
As per the labeling on the product’s official website, the Physio Flex Pro contains the following ingredients –
1. Selenium (as Selenium citrate) – 200mcg
2. Glucosamine HCl – 500mg
3. Bromelain (Ananus comosus) stem – 300mg
4. Ginger extract (Zingiber officinalis) root – standardized to contain 5% gingerols – 250mg
5. Turmeric extract (Curcuma longa) – standardized to contain 95% curcuminoids root – 200mg
6. Chondroitin sulfate – 100mg
7. Methylsulfonylmethane (MSM) – 100mg
8. Bioperine (Black pepper fruit extract) – 10mg
9. Other ingredients – Vegetable cellulose (capsules), Silicon dioxide, Magnesium stearate
Physio Flex Pro Reviews On Its Ingredients
SELENIUM
Selenium is an essential nutrient and trace element and has beneficial effects on human health. It is well-known as a cofactor for enzymes responsible for antioxidant activity and for regulating inflammatory processes in the body.
A deficiency of selenium can be associated with various diseases such as cardiovascular diseases, cancer, liver diseases, and viral diseases including COVID-19. Additionally, its deficiency is associated with osteoarthritis, a degenerative disease characterized by cartilage destruction, and arthropathy-Kashin-Beck disease (KBD), a skeletal developmental disorder. Excessive selenium can, however, be toxic and can contribute to joint disease (2, 3). Thus, mixed reviews are available on selenium depending on its dosages in Physio Flex Pro.
What is Kashin Beck Disease?
Kashin Beck Disease is a chronic joint disease and has been related to selenium deficiency in certain regions of Siberia, Korea, and China. Kashin Beck disease has been linked to a multifactorial etiology including both nutritional as well as other factors such as genetic, immunological, infectious, and environmental factors. The Kashin Beck disease is seen in children and its severity increases with age.
GLUCOSAMINE
Glucosamine (2-Amino-2-Deoxy-D-Glucopyranose)Â is one of the structural components of cartilage. Glucosamine is a dietary supplement used for managing pain in osteoarthritis. It has shown beneficial effects in several experimental and human studies. Though studies are also available to show that it might be one of the disease-modifying osteoarthritic drugs (DMOADs), the chondrocyte-modulating action has not been substantiated. Further, even its therapeutic efficacy has been controversial.Â
When compared to a large NIH study and a European study, opposite findings were observed. While the large NIH study observed no effect of glucosamine HCl on knee pain improvement in osteoarthritis patients, a European study observed improvement in knee function with glucosamine sulfate (5). Since Physio Flex Pro contains glucosamine HCl and not sulfate, it is not clear whether it will be effective in symptoms of knee osteoarthritis.
BROMELAIN (Ananas comosus stem)
Bromelain is a proteolytic enzyme obtained from the stem of pineapples (Ananas comosus). Several studies have proven the anti-inflammatory potential of bromelain. It also possesses antimicrobial actions. It has been licensed as a traditional or complementary medicine for the treatment of osteoarthritis. In addition to its anti-inflammatory potential, it is used widely as an analgesic to treat muscular and arthritic pain (6).
GINGER EXTRACT
Physio Flex Pro contains ginger root extract standardized to contain 5% gingerols. Ginger has long been used as a traditional medicine for musculoskeletal pain and several reviews are available on the same.
Though several studies have reported the pain-relieving action of ginger and gingerols, a recent systematic review and meta-analysis examined the effect of several clinical studies of ginger on pain and other symptoms in knee osteoarthritis and observed no significant differences. The meta-analysis concluded that there is insufficient evidence to support the use of ginger in knee osteoarthritis (7).
TURMERIC EXTRACT
Physio Flex Pro contains turmeric root extract standardized to contain 95% curcuminoids which have well-established anti-inflammatory actions and several reviews are available on the same. In a clinical study on knee osteoarthritis patients, it was reported that the bioavailable turmeric extract was as effective as paracetamol in reducing pain and even more effective in reducing inflammation as evidenced by a reduction in C-reactive protein and cytokine levels (8).
CHONDROITIN SULFATE
Like glucosamine, chondroitin sulfate is also sold as a dietary supplement for knee osteoarthritis. It is also considered as DMOADs based on the measurement of joint space narrowing on radiographs. Several studies have proven the symptomatic efficacy of chondroitin in knee osteoarthritis, but its disease-modifying effects have been controversial.
Both chondroitin and glucosamine exert beneficial effects in experimental cell culture studies on cells involved in osteoarthritis such as those derived from synovial joints, chondrocytes, and cells from the subchondral bone. Further, they both have been reported to increase type 2 collagen and reduce inflammatory mediators. Physio Flex Pro reviews also indicate that they might help reduce inflammatory mediators. Several International guidelines recommend both chondroitin and glucosamine for the treatment of hip and knee osteoarthritis (9).
METHYLSULFONYLMETHANE (MSM)
Methylsulfonylmethane (MSM) is a popular dietary supplement with effects in reducing inflammation, joint, and muscle pain, and reducing free radicals. It is well tolerated with only fewer side effects (10). Though several studies report its beneficial effects, and a recent systematic review of studies reported significant improvement in pain by MSM, however, the studies’ methodology and quality were not appropriate to derive the proper conclusion (11). Hence, further studies are required to confirm its reported effects.
BIOPERINE (Black Pepper Fruit Extract)
Bioperine is a patented extract obtained from black pepper fruits (Piper nigrum) standardized minimum to 95% Piperine. Bioperine is a natural bioavailability enhancer manufactured by Sabinsa Corporation. Piperine has well-documented anti-inflammatory, antinociceptive, and antiarthritic effects (12).  However, piperine can also be obtained from Piper longum and has several therapeutic actions (13).Â
As per the official website of Bioperine (14), it can be administered together with several nutrients to enhance their bioavailability such as herbal extracts of Curcuma longa, Withania somnifera, fat and water-soluble vitamins, amino acids like lysine, leucine, threonine, etc., minerals like calcium, iron, zinc, selenium, magnesium, etc.Â
Piperine obtained from Piper nigrum has demonstrated antioxidant, and anti-inflammatory actions to support joint health and shown beneficial effects in osteoarthritis and rheumatoid arthritis in preclinical and clinical studies. Reviews on available studies indicate the positive role of Bioperine as part of Physio Flex Pro joint supplement.Â
What are the benefits of Physio Flex Pro Joint Supplement?
The Physio Flex Pro Joint Supplement has claimed to have several potential benefits for individuals looking to support joint health. Some of these potential benefits include:
1. Reduced joint stiffness
The ingredients in Physio Flex Pro Joint Supplement can help reduce joint stiffness, which can improve mobility and flexibility.
2. Alleviated joint-related discomfort
Physio Flex Pro Joint Supplement may help alleviate joint-related discomfort, including joint pain and inflammation.
3. Improved joint mobility
By supporting the structure and function of joints, the Physio Flex Pro Joint Supplement may help improve joint mobility.
4. Natural ingredients
Physio Flex Pro Joint Supplement contains a blend of natural ingredients that are safe and effective for supporting joint health.
5. Easy to use
Physio Flex Pro Joint Supplement is easy to use and can be taken as a daily supplement to support joint health.
Side effects of Physio Flex Pro Joint Supplement
Gastrointestinal upset
Some individuals may experience gastrointestinal side effects including GI upset, such as nausea, vomiting, diarrhea, or constipation when taking Physio Flex Pro Joint Supplement. This is typically mild and goes away once the body adjusts to the supplement.
Allergic reactions
Rarely, individuals may experience an allergic reaction to one of the ingredients in Physio Flex Pro Joint Supplement. Signs of an allergic reaction may include itching, swelling, rash, or difficulty breathing. If you experience any of these symptoms, stop taking the supplement and seek medical attention immediately.
Blood sugar changes
Glucosamine, one of the main ingredients in Physio Flex Pro Joint Supplement, may affect blood sugar levels in individuals with diabetes. If you have diabetes, it is important to monitor your blood sugar levels closely while taking the supplement.
Drug Interactions (Interactions with other medicines)
Physio Flex Pro Supplement may interact with certain medications, such as blood thinners, nonsteroidal anti-inflammatory drugs (NSAIDs), or insulin. If you are taking any medications, it is important to speak with your healthcare provider before starting the supplement as Physio Flex Pro may cause drug interactions and side effects.Â
Headaches
Some individuals may experience headaches as a side effect when taking Physio Flex Pro Joint Supplement. This is typically mild and goes away once the body adjusts to the supplement.
It is important to note that the above side effects are rare, and most individuals tolerate Physio Flex Pro Joint Supplement well as per the reviews. However, we take no responsibility for the reviews reported on various websites. If you experience any adverse effects while taking the supplement, it is important to speak with your healthcare provider. Additionally, it is important to follow the recommended dosage and not exceed the recommended daily intake of the supplement.Â
Further, it is important to note that the dietary supplement industry is not well-regulated, and there are no requirements for safety or efficacy testing before products are marketed to consumers. This means that some products may contain harmful ingredients or may not contain the ingredients listed on the label. Additionally, some dietary supplement manufacturers make misleading or false claims about the benefits of their products. This can lead consumers to believe that the supplements are more effective than they actually are. Taking more than the recommended dose of a dietary supplement can have side effects, and be harmful, and the same may apply to Physio Flex Pro.Â
Conclusion
In conclusion, Physio Flex Pro Joint Supplement is a nutritional supplement designed to support joint health and alleviate joint-related discomfort. The supplement contains a blend of natural ingredients, including glucosamine, chondroitin, Bioperine, and MSM, which work together to support joint function. The potential claimed benefits of Physio Flex Pro Joint Supplement include reduced joint stiffness, alleviated joint-related discomfort, improved joint mobility, natural ingredients, and ease of use. If you are looking to support your joint health, Physio Flex Pro Joint Supplement may be a helpful addition to your wellness routine. However, it is important to be aware of the potential risks associated with dietary supplements and to speak with a healthcare provider before starting any new supplement regimen.
Sources
- Physio Flex Pro Official Website
- Selenium
- The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies
- Kashin Beck Disease: more than just osteoarthrosis
- Glucosamine and Chondroitin for Osteoarthritis
- Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective
- Effectiveness of Ginger on Pain and Function in Knee Osteoarthritis: A PRISMA Systematic Review and Meta-Analysis
- Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol
- What is the current status of chondroitin sulfate and glucosamine for the treatment of knee osteoarthritis?
- Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis
- Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1β-stimulated fibroblast-like synoviocytes and in rat arthritis models
- A systematic review on Piper longum L.: Bridging traditional knowledge and pharmacological evidence for future translational research
- Bioperine (bioperine.com)
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