Are you seeking a natural approach to your joint pain, stiffness, inflammation, and other bone and joint health-related problems? Are you currently experiencing side effects from medications prescribed for joint pain relief? Are you looking to safeguard your joints from age-related degeneration in the future? If the answer to any of the above questions is yes, then Flexoplex, a magical bone and joint health supplement, may be an option for you. In this blog, we examined the Flexoplex reviews and available scientific literature pertaining to various ingredients present in Flexoplex, as well as the potential side effects, if any, to present a balanced and unbiased assessment of whether Flexoplex can be the dietary supplement of choice for your joint pain relief and for maintaining optimal bone and joint health.
Joint pain and stiffness are one of the most common problems of middle age in the United States. A joint is a place where two or more bones articulate to enable movement capabilities. With the natural aging process too, our joints become less flexible as the amount of lubricating fluid inside the joint reduces and the cartilage becomes thinner. In addition, there are several other causes of joint pain, which include various types of injuries or medical conditions such as rheumatoid arthritis, osteoarthritis, gout, bone, and joint infections, etc.Â
Arthritis is one of the most common causes of joint pain. It is an inflammatory condition of the joints characterized by pain, stiffness, reduced range of motion, and cartilage degeneration. While pain and stiffness are managed clinically by painkillers and anti-inflammatory medicines, these medicines are usually associated with a lot of side effects. Hence, dietary supplements play an important role in the treatment of bone and joint health problems including pain relief. Flexoplex is one such magical bone and joint health supplement that contains various natural ingredients that work together to relieve the symptoms and improve joint function.
How Does Flexoplex Work?
Flexoplex contains Chondroitin sulfate and Glucosamine sulfate sodium salt as its major constituents along with a unique blend of ingredients such as methylsulfonylmethane (MSM), Cat’s claw bark powder, Rutin, Indian Frankincense (Boswellia Serrata), Hyaluronic acid, Bromelain, Boron, etc. These ingredients work together to relieve pain and inflammation, reduce stiffness, improve mobility, prevent joint degradation, regenerate damaged tissue, and protect subchondral bone tissue located deep in the articular cartilage.
Wow, that is some power-packed ingredients showing an array of benefits and actions to protect bone and joint health, and remarkably, all combined in a single formula. No wonder the reviews on the efficacy of Flexoplex are so amazing. Let us examine each of the above-mentioned ingredients one by one to see how Flexoplex is magically the best dietary supplement on earth.
Flexoplex Ingredients
1 bottle of Flexoplex contains 60 tablets with a serving size of 2 tablets twice daily. As per the product label, Flexoplex contains the following ingredients (1):
- Chondroitin sulfate, 600mg
- Glucosamine sulfate sodium salt, 750mg
- Blend of Ingredients, 697mg
- Methylsulfonylmethane (MSM)
- Cat’s Claw Bark Powder
- Rutin
- Indian Frankincense (Boswellia Serrata)
- Hyaluronic acid
- Soy Lecithin Powder
- Bromelain
- Boron
- Trypsin
Flexoplex Reviews On Its Ingredients
Though the Flexoplex ingredients are all-natural ingredients, it is crucial for consumers to conduct thorough research on any dietary supplement product reviews before use to ensure its effectiveness and safety. One must keep in mind that dietary supplements are regulated as food, rather than medicine. Hence, it is important to look at each product ingredient’s label and scrutinize each ingredient to ensure the product is efficacious and safe. We have made this simple for you through this blog.
While the ingredient list of Flexoplex is quite long, we searched the scientific literature and reviews on all the ingredients of Flexoplex and strived to provide a balanced view regarding the possible pros and cons for you to judge if Flexoplex would work for you:
1. Chondroitin Sulfate
Chondroitin sulfate is found in human connective tissues including cartilage, bone, cornea, ligament, tendons, and skin. Sources of chondroitin used in nutritional supplements are animal sources such as the bovine trachea, pork, shark cartilage, etc. As mentioned on the product label, the chondroitin (600mg) in Flexoplex is from a bovine source.
For joint pain relief, chondroitin is popularly used alone or in combination with glucosamine in osteoarthritis and other types of joint pain. The advantages of chondroitin are being a natural supplement, and one can avoid the adverse effects associated with painkiller medicines which commonly cause gastric issues and kidney damage on long-term use.
There have been several efficacy and toxicity studies conducted on the chondroitin supplement. In a multi-country clinical trial conducted in France, Germany, Poland, and Spain on patients with knee osteoarthritis, it was observed that the combination of chondroitin and glucosamine reduced pain, joint stiffness, and joint swelling and had comparable efficacy as compared to the marketed analgesic drug celecoxib after 6 months of treatment. In addition, it was found to have a good safety profile. These encouraging findings on Chondroitin were reported in the British Medical Journal (2).
2. Glucosamine Sulfate
Glucosamine is an important constituent of articular cartilage. Cartilage help protects our bone and joints. It is notable that the sulfate form of glucosamine has been approved in Europe for the treatment of osteoarthritis and for joint health and is available as an over-the-counter dietary supplement in the United States (3). Further, glucosamine sulfate has been recommended in the treatment of joint and osteoarthritis pain as per two important international guidelines, OARSI (Osteoarthritis Research Society International) and EULAR (European Alliance of Associations for Rheumatology).
For commercial use, glucosamine is extracted by hydrolyzing shellfish shells or animal skeletons and used as a drug. Further, the combination of chondroitin and glucosamine has proven to be beneficial as per a large number of studies. Flexoplex contains both of these to provide a synergistic effect on bone and joint health with several positive reviews.Â
3. Methyl Sulfonyl Methane (MSM)
Methylsulfonylmethane (MSM), a natural organosulfur, is widely used in traditional or complementary medicine for its antioxidant and anti-inflammatory effects. Therefore, MSM has an important place in the treatment of arthritis which is mainly an inflammatory condition of the joints.Â
It has been reported that MSM works in improving joint health in several ways such as by a) reducing pain, stiffness, and inflammation, b) decreasing cartilage degeneration, c) improving the range of motion and physical function, d) reducing muscle soreness, and e) decreasing oxidative damage (4).Â
MSM is generally considered to be safe and well-tolerated. MSM in Flexoplex can produce a wide array of benefits as described above including prevention of age-related cartilage degeneration.Â
4. Rutin
Rutin is a natural flavonoid compound that has well-established antioxidant and anti-inflammatory properties. Rutin has been demonstrated to reduce inflammatory cytokines in several experimental studies. Though several preclinical studies describe the benefits of Rutin in inflammation, we could not find many clinical studies reported on Rutin alone. However, it has been demonstrated to be beneficial in combination with other ingredients. Infact, Flexoplex contains Rutin with all other beneficial ingredients with positive reviews. In one of the studies, Rutin was combined with bromelain and trypsin for the treatment of arthritis and to improve pain, swelling, and stiffness (5).
5. Cat's Claw Bark Powder
Cat’s claw has been used in South American traditional medicine for centuries. Its name is derived from curved thorns and woody vines resembling Cat’s claws. The extract of the plant Uncaria tomentosa, mainly the bark extract, is used in traditional medicine for its well-known anti-inflammatory and pain-relieving effects. It is a widely used herbal medicine for inflammatory bone and joint health conditions. Cat’s claw is often used in combination with chondroitin and glucosamine for the treatment of arthritis with proven benefits (6).
6. Indian Frankincense (Boswellia Serrata)
Boswellia Serrata is a plant that is native to India. Boswellic acid is the major active ingredient of this plant and has been reported to be the major active ingredient responsible for efficacy in rheumatoid arthritis and osteoarthritis. It is one of the ingredients in Flexoplex and several studies and reviews are available to show that both the plant extract and its active ingredients improve pain, and physical function and reduce inflammation to improve joint health.
In a systematic review and meta-analysis of 7 clinical trials involving 545 patients, it was reported that Boswellia extract, when used for 4 weeks, relieved pain and stiffness and improved joint mobility. Further, the study reported the extract to be safe for human consumption (7). Â These studies provide support for the use of this Flexoplex ingredient in joint pain relief and inflammation.
7. Hyaluronic Acid
Hyaluronic acid, a glycosaminoglycan, is an important component of cartilage and is present around cells of the cartilage protecting it from degradation. It is also present within the synovial fluid of the knee joint providing lubrication to the joint. In osteoarthritis, lower levels of hyaluronic acid are observed necessitating supplementation.
Flexoplex contains hyaluronic acid as Sodium hyaluronate which, as per reviews in scientific literature, can lubricate the joint and help improve joint health. A systematic review of 7 randomized clinical trials and 10 clinical studies (a total of 17 studies) revealed that hyaluronic repeated injections in the knee improved joint health and reduced pain in knee osteoarthritis and that there were no safety concerns (8).
8. Bromelain
Bromelain, a protease, is derived from the stems of pineapples. A protease enzyme breaks down other proteins if they have cysteine amino acids. Too much stress or trauma release prostaglandins which are inflammatory. Bromelain controls their synthesis and prevents inflammation. It has proven pain-relieving effects too. Bromelain is one of the ingredients in Flexoplex and is hence beneficial as a pain reliever and anti-inflammatory as per reviews of the scientific literature. In a clinical study on arthritis, bromelain significantly reduced pain which was comparable to a marketed painkiller medicine (9).
9. Boron
The trace mineral Boron is an essential micronutrient for healthy bones and joints. There are several benefits of Boron. Flexoplex contains Boron aspartate which can help bone and joint health in several ways: a) increase bone growth and maintenance, b) promote wound healing, c) help effectively utilize vitamin D and other hormones, d) help absorb Ca and Mg, and e) produce anti-inflammatory actions.
Interestingly, researchers found that in areas where boron intake is usually higher, the incidence of arthritis was extremely low. Human clinical trials have found boron to be a safe and effective treatment for osteoarthritis (10).
10. Soy Lecithin Powder
Lecithins are a common food additive that has bone-protecting properties. Studies demonstrate that Soy isoflavones protect against bone loss. Hence, a combination of soy isoflavone with lecithins can synergize for bone protection (11). Flexoplex contains soy lecithin powder which can help protect the bones. This makes Flexoplex a dual bone-joint health supplement.
11. Trypsin
Trypsin is an enzyme that cleaves proteins and helps tissue repair following trauma or orthopedic injuries. In a clinical study, trypsin, bromelain, and other ingredients helped relieve pain in temporomandibular joint osteoarthritis (5). Trypsin, which is present in Flexoplex, has anti-inflammatory, antioxidant, and anti-infective properties.
What benefits Flexoplex provides and Why Is It a Magical Supplement?Â
Based on the reviews of available clinical studies on each ingredient of Flexoplex, there are some obvious evidence-based benefits as described below:
1. Alleviates Joint Pain
The ingredients present in Flexoplex all work together to alleviate pain associated with medical conditions such as rheumatoid arthritis, osteoarthritis, or other joint problems due to injury or trauma. This has been proven time and again by a variety of clinical studies and trials on its major ingredients.
2. Reduces Inflammation
Flexoplex help reduce inflammation by reducing the release of pro-inflammatory cytokines responsible for inflammation in the joints.
3. Reduces Stiffness and Improves Joint Mobility
The natural ingredients present in Flexoplex synergize to decrease inflammation which further reduces stiffness and helps in increasing the range of motion thereby improving joint mobility.
4. Protects Subchondral Bone
Most of the other dietary joint supplements are silent on the effects on the subchondral bone. The ingredients present in Flexoplex protect the bone that is behind the articular cartilage thereby making Flexoplex a dual bone and joint health supplement having a unique advantage over all other supplements.
5. Synergistic Cartilage Protection
The combination of chondroitin with glucosamine sulfate has been proven to be synergistic as chondroprotective (12). Chondroprotection means that the drugs have the potential to delay the narrowing of the joint space which is a characteristic feature of arthritis. It also means the protection of the cartilage cells. However, a few studies report that this combination is not enough. Therefore, Flexoplex provides a blend of ingredients working synergistically to provide protection for all bone and joint health-related issues.
6. Safe and Natural
Flexoplex is made from natural ingredients which are considered safe. Studies also prove that Flexoplex is free from any significant toxic effects. Additionally, by using Flexoplex, one can avoid the adverse effect of non-steroidal anti-inflammatory drugs available in the market that can cause stomach ulcers, kidney damage, etc. Â
7. GMP-compliant
Flexoplex is manufactured in a GMP-compliant facility which gives confidence to the consumers that it follows good quality control.
Who Can Benefit from Flexoplex, A Bone and Joint Health Supplement?
Flexoplex is a unique dietary supplement that contains a blend of natural ingredients that have been evidenced to improve bone and joint health.
Based on the reviews of clinical studies on its ingredients, Flexoplex can benefit people suffering from chronic joint conditions such as rheumatoid arthritis, osteoarthritis, chronic inflammatory conditions, or those experiencing pain and inflammation due to trauma or orthopedic injuries.
Additionally, Flexoplex may be a natural alternative for those who have been taking allopathic medicines for their pain and inflammation and are experiencing serious side effects with them.
Flexoplex Reviews - Are there any Flexoplex Side Effects?
A few points, however, may be worth noting.
- If you are allergic to Shellfish or Soy products, Flexoplex may not be for you. This has been also stated on the official website that if you are allergic to certain foods, do not use Flexoplex.
- Flexoplex is not advisable if you are suffering from a serious medical condition, you are pregnant, or breastfeeding. it is always advisable to consult your healthcare provider (1).
- Chondroitin sulfate may also interact with certain medications, including blood thinners, and should not be taken by people with bleeding disorders or a history of blood clots.
Overall, the ingredients present in Flexoplex are regarded as safe for human consumption and we could not find any serious side effects reported in the scientific literature or any adverse Flexoplex reviews.
Who Manufactures Flexoplex?
Flexoplex is manufactured by Pharmaxa Labs, which has been manufacturing quality health products for more than 20 years. The Flexoplex tablets are manufactured in an FDA-approved facility that follows Good Manufacturing Practices (GMP-compliant facility).
Further, as mentioned on the official website, FlexoPlex has been added to the Dietary Supplement Label Database (DSLD). DSLD is maintained by the National Institute of Health (NIH) and contains catalogs of all the information printed on the labels of dietary supplement products sold in the United States.
How to Consume Flexoplex?
It is recommended to take 2 tablets of Flexoplex twice daily with a glass of water. One can take two tablets in the morning, about 15 min before breakfast, and two in the evening, about 1 hour before going to bed. Further, it is recommended to take Flexoplex for 6 months to notice a significant improvement in joint health, however, some people observe improvement within 2 weeks. Â
Where to Buy Flexoplex?
Conclusion
The reviews on Flexoplex and the scientific literature available on the ingredients found in Flexoplex indicate it to be a beneficial supplement for addressing your bone and joint health-related concerns, especially for those experiencing age-related deterioration or those affected by osteoarthritis which involves progressive structural or metabolic changes in joint tissue, or those looking to protect their bone and joint health.
It is noteworthy that in chronic arthritis and severe joint degeneration, the subchondral bone also gets affected. Hence, when considering any dietary supplement, it becomes crucial to focus on protecting both joints and the subchondral bone. Flexoplex stands out as an exceptional supplement in this regard, that not only protects joint health but also contains ingredients specifically aimed at preserving bone health. This distinctive feature gives Flexoplex an edge over other joint supplements available commercially.
The above attributes and positive reviews on its ingredients indeed make Flexoplex a magical bone and joint health supplement. As it not only aids in relieving joint pain and discomfort but also asserts to impede further cartilage degeneration, promote cartilage regeneration, reduce inflammation, and protect the subchondral bone. Flexoplex, therefore, offers a diverse range of advantages for safeguarding the health of bones and joints. However, it is important to note that this information does not constitute medical advice, and it is always recommended to consult your healthcare professional before starting any new dietary supplement.
Sources
- https://www.myflexoplex.com/
- https://ard.bmj.com/content/75/1/37
- https://arthritis-research.biomedcentral.com/articles/10.1186/ar3657
- https://www.mdpi.com/2072-6643/9/3/290
- https://pubmed.ncbi.nlm.nih.gov/28764284/
- https://www.ncbi.nlm.nih.gov/books/NBK548323/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368679/
- https://www.sciencedirect.com/science/article/pii/S0049017217306509?via%3Dihub
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067380/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8446686/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381474/
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